2021年度業績

【英文論文】
Sato R, Imamura K, Semba T, Tomita Y, Saeki S, Ikeda K, Komohara Y, Suzuki M, Sakagami T, Saya H, Arima Y. TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma.
Cancer Research. 2022;15;81(18):4751-4765

Okabayashi H, Machida H, Masunaga A, Ichiyasu H, Sakagami T. 18 F-FDG uptake in accessory respiratory muscles shows the respiratory effort of patients with pleuroparenchymal fibroelastosis. Respirol Case Rep. 2022;10(2): e0900.

Anai M, Yoshida C, Ozono K, Furukawa H, Ishimaru Y, Sakata S, Saruwatari K, Muramoto K, Tomita Y, Saeki S, Ichiyasu H, Sakagami T. Successful concomitant therapy with mepolizumab and dupilumab for atypical eosinophilic granulomatosis with polyangiitis.
Allergol Int. 2022;21: S1323-8930(21)00142-8.

Hidekawa C, Yoshimi R, Kishimoto D, Kato H, Mitsuhashi M, Sakurai N, Sato Y, Uehara T, Iizuka Y, Komiya T, Hamada N, Nagai H, Soejima Y, Kamiyama R, Takase-Minegishi K, Kirino Y, Sakagami T, Nakajima H. Anti-interferon-γ antibody-seropositive disseminated nontuberculous mycobacterial infection mimicking POEMS and TAFRO syndromes: a case report.
Intern Med. 2022; Aug 1;61(15):2377-2385.

Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M. Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Cancer Sci. 2022;113(1):287-296.

Mizugaki H, Oizumi S, Fujita Y, Harada T, Nakahara Y, Takashina T, Ko R, Watanabe K, Hotta T, Minemura H, Saeki S, Asahina H, Nakamura K, Nakamura H, Hosoda F, Yagishita S, Hamada A. Pharmacokinetic and pharmacogenomic analysis of low-dose afatinib treatment in elderly patients with EGFR mutation-positive non-small cell lung cancer.
Eur J Cancer. 2022;160:227-234.

Sakata S, Otsubo K, Yoshida H, Ito K, Nakamura A, Teraoka S, Matsumoto N, Shiraishi Y, Haratani K, Tamiya M, Ikeda S, Miura S, Tanizaki J, Omori S, Yoshioka H, Hata A, Yamamoto N, Nakagawa K. Real-world data on NGS using the Oncomine DxTT for detecting genetic alterations in non-small-cell lung cancer: WJOG13019L.
Cancer Sci. 2022;113(1):221-228.

Tokunaga K, Ejima T, Nakashima T, Kuwahara M, Narimatsu N, Sagishima K, Mizumoto T, Sakagami T, Yamamoto T. A novel technique for assessment of post-extubation airway obstruction can successfully replace the conventional cuff leak test: a pilot study.
BMC Anesthesiol. 2022;2;22(1):38.

Yang L., Zhou Y., Wang G., Liu D., Chen B., Pu D., Correale P., Rades D., Tomita Y., Inno A., Santarpia M., Li Y. & Li W. Clinical features and prognostic factors of combined small cell lung cancer: development and validation of a nomogram based on the SEER database.
Transl Lung Cancer Res. 2021;10, 4250-4265.

Qiu B., Cai K., Chen C., Chen J., Chen KN., Chen Q.X., Cheng C., Dai TY., Fan J., Fan Z., Hu J., Hu W.D., Huang Y.C., Jiang G.N., Jiang J., Jiang T., Jiao W.J., Li HC., Li Q., Liao Y.D., Liu H.X., Liu J.F., Liu L, Liu Y., Long H., Luo QQ., Ma H.T., Mao NQ., Pan X.J., Tan F., Tan L.J., Tian H., Wang D., Wang W.X., Wei L., Wu N., Wu QC., Xiang J., Xu SD., Yang L., Zhang H., Zhang L., Zhang P., Zhang Y., Zhang Z., Zhu K., Zhu Y., Um SW., Oh IJ., Tomita Y., Watanabe S., Nakada T., Seki N., Hida T., Sasada S., Uchino J., Sugimura H., Dermime S., Cappuzzo F., Rizzo S., Cho W.CS., Crucitti P., Longo F., Kye Lee K.Y, Ruysscher D.D., Vanneste B.G.L., Furqan M., Sieren J.C., Yendamuri S, Merrell K.W., Molina J.R., Metro G., Califano R., Bongiolatti S., Provencio M., Hofman P., Gao S. & He J. Expert consensus on perioperative immunotherapy for local advanced non-small cell lung cancer.
Transl Lung Cancer Res. 2021;10, 3713-3736.

Carraway H.E., Sawalha Y., Gojo I., Lee ML., Lee S., Tomita Y., Yuno A., Greer J., Smith B.D., Pratz K.W., Levis M.J., Gor S.D., Ghosh N., Dezern A., Blackford A.L., Baer M.R., Gore L., Piekarz R., Trepel J.B. & Karp J.E. Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Leukemia Research 2021;106707-106707.

Yang Y., Lu J., Ma Y., Xi C., Kang J., Zhang Q., Jia X., Liu K., Du S., Kocher F., Seeber A., Gridelli C., Provencio M., Seki N., Tomita Y. & Zhang X. Evaluation of the reporting quality of clinical practice guidelines on lung cancer using the RIGHT checklist.
Transl Lung Cancer Res. 2021;10: 2588-2602.

Hirose M, Ishimaru Y, Sakata S, Sakagami T. Rapid shrinkage of retroperitoneal lymphangioleiomyoma after sirolimus initiation.
Intern Med. 2021; Jul 1;61(13):2081-2082.

Asako M, Matsunaga H, Nakahara W, Ikeda M, Mima F, Minami R, Sekiguchi M, Oka K, Wada N, Suzuki K, Yoshizawa K, Sakagami T, Ueda S. Mycobacterial lymphadenitis without granuloma formation in a patient with anti-interferon-gamma antibodies.
Int J Hematol. 2021;114(5):630-635.

Akter S, Migiyama Y, Tsutsuki H, Ono K, Hamasaki C, Zhang T, Miyao K, Toyomoto T, Yamamoto K, Islam W, Sakagami T, Matsui H, Yamaguchi Y, Sawa T. Development of potent antipseudomonal β-lactams by means of polycarboxylation of aminopenicillins.
Microbiol Immunol. 2021;65(10):449-461.

Uno S, Uehara E, Kimura T, Sakagami T, Namkoong H, Uchida S, Uwamino Y, Hasegawa N. R-CHOP Chemotherapy for Disseminated Mycobacterium avium Complex Disease due to Anti-Interferon-Gamma Autoantibodies: A Case Report.
Open Forum Infect Dis. 2021;10;8(6): ofab181.

Matsubara E, Komohara Y, Shinchi Y, Mito R, Fujiwara Y, Ikeda K, Shima T, Shimoda M, Kanai Y, Sakagami T, Suzuki M. CD163-positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma.
Pathol Int. 2021;71(10):666-673.

Masunaga A, Takemura T, Ichiyasu H, Migiyama E, Horio Y, Saeki S, Hirosako S, Mori T, Suzuki M, Kohrogi H, Sakagami T. Pathological and clinical relevance of selective recruitment of Langerhans cells in the respiratory bronchioles of smokers.
Respir Investig. 2021;59(4):513-521.

Anai M, Akaike K, Iwagoe H, Akasaka T, Higuchi T, Miyazaki A, Naito D, Tajima Y, Takahashi H, Komatsu T, Masunaga A, Kishi H, Fujii K, Fukuda K, Tomita Y, Saeki S, Ichiyasu H, Sakagami T. Decrease in hemoglobin level predicts increased risk for severe respiratory failure in COVID-19 patients with pneumonia.
Respir Investig. 2021;59(2):187-193.

Okabayashi H, Kitamura H, Ikeda S, Sekine A, Oda T, Baba T, Hagiwara E, Sakagami T, Ogura T. Impact of interstitial pneumonia complications on palliative medication for terminal lung cancer: A single-center retrospective study.
Respir Investig. 2021;59(6):859-864.

Mochizuka Y, Kono M, Hirama R, Oshima Y, Takeda K, Tsutsumi A, Miwa H, Miki Y, Hashimoto D, Kimura T, Sakagami T, Nakamura H. Endobronchial Lesions from Disseminated Mycobacterium avium Infection in a Patient with Anti-interferon-gamma Autoantibodies.
Intern Med. 2021;15;60(20):3267-3272.

Tamanoi D, Saruwatari K, Imamura K, Sato R, Jodai T, Hamada S, Tomita Y, Saeki S, Ueno S, Yonemura Y, Ichiyasu H, Sakagami T. A Case of Pembrolizumab-related Immune Thrombocytopenia in a Patient with Lung Adenocarcinoma Treated by Radiotherapy: Potential Immune-related Adverse Event Elicited by Radiation Therapy.
Intern Med. 2021; Jun 1;61(11):1731-1734.

Okabayashi H, Kitamura H, Ikeda S, Sekine A, Oda T, Baba T, Hagiwara E, Sakagami T, Ogura T. Patients with Terminal Interstitial Pneumonia Require Comparable or More Palliative Pharmacotherapy for Refractory Dyspnea than Patients with Terminal Lung Cancer.
Palliat Med Rep. 2021;16;2(1):188-193.

Sakai K, Tsuboi M, Kenmotsu H, Yamanaka T, Takahashi T, Goto K, Daga H, Ohira T, Ueno T, Aoki T, Nakagawa K, Yamazaki K, Hosomi Y, Kawaguchi K, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Okabe K, Yamamoto N, Nishio K. Tumor mutation burden as a biomarker for lung cancer patients treated with pemetrexed and cisplatin (the JIPANG-TR).
Cancer Sci. 2021;112(1):388-396.

Miyawaki T, Kenmotsu H, Harada H, Ohde Y, Chiba Y, Haratani K, Okimoto T, Sakamoto T, Wakuda K, Ito K, Uemura T, Sakata S, Kogure Y, Nishimura Y, Nakagawa K, Yamamoto N. Phase II study of multidisciplinary therapy combined with pembrolizumab for patients with synchronous oligometastatic non-small cell lung cancer TRAP OLIGO study (WJOG11118L).
BMC Cancer. 2021; 21(1):1121.

Ito K, Yamanaka T, Hayashi H, Hattori Y, Nishino K, Kobayashi H, Oya Y, Yokoyama T, Seto T, Azuma K, Fukui T, Kozuki T, Nakamura A, Tanaka K, Hirano K, Yokoi T, Daga H, Sakata S, Fujimoto D, Mori M, Maeno K, Aoki T, Tamura A, Miura S, Watanabe S, Akamatsu H, Hataji O, Suzuki K, Hontsu S, Azuma K, Bessho A, Kubo A, Okuno M, Nakagawa K, Yamamoto N. Sequential therapy of crizotinib followed by alectinib for non-small cell lung cancer harbouring anaplastic lymphoma kinase rearrangement (WJOG9516L): A multicenter retrospective cohort study.
Eur J Cancer. 2021;145:183-193.

Academic Guidelines Promotion Group (Tokunaga K et al.). The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).
J Intensive Care. 2021;9(1):53

Academic Guidelines Promotion Group (Tokunaga K et al.). The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).
Acute Med Surg. 2021;8(1): e659.

Ideguchi H, Ichiyasu H, Fukushima K, Okabayashi H, Akaike K, Hamada S, Nakamura K, Hirosako S, Kohrogi H, Sakagami T, Fujii K. Validation of a breath-holding test as a screening test for exercise-induced hypoxemia in chronic respiratory diseases.
Chron Respir Dis. 2021;18:14799731211012965.


Sakamoto N, Hamada N, Okamoto M, Tobino K, Ichiyasu H, Ishii H, Ichikado K, Morimoto S, Hosogaya N, Mukae H. Efficacy and safety of nintedanib in Japanese patients with early-stage idiopathic pulmonary fibrosis: a study protocol for an observational study.
BMJ Open. 2021;11(6):e047249.

Kondoh Y, Makino S, Ogura T, Suda T, Tomioka H, Amano H, Anraku M, Enomoto N, Fujii T, Fujisawa T, Gono T, Harigai M, Ichiyasu H, Inoue Y, Johkoh T, Kameda H, Kataoka K, Katsumata Y, Kawaguchi Y, Kawakami A, Kitamura H, Kitamura N, Koga T, Kurasawa K, Nakamura Y, Nakashima R, Nishioka Y, Nishiyama O, Okamoto M, Sakai F, Sakamoto S, Sato S, Shimizu T, Takayanagi N, Takei R, Takemura T, Takeuchi T, Toyoda Y, Yamada H, Yamakawa H, Yamano Y, Yamasaki Y, Kuwana M.2020 guide for the diagnosis and treatment of interstitial lung disease associated with connective tissue disease.
Respir Investig. 2021;59(6):709-740.